Reference article

Considering the efficiency at work and the fact that my skills in English are not very solid, I investigated the use of DeepL to complete the translation of the official website and the daily blog. The free version of DeepL has a lot of restrictions, when buying the paid version of DeepL Pro in China, DeepL official website for supporting China 🇨🇳 region, the solution is to use Virtual VISA service, you can go here for the specific process. ...

Architecture

Getting Started The beginning of 2020 when they have planned their own future direction is to ARM devices edge computing direction development, is expected in the next 3-5 years ARM platform will rise in various computing fields, from smart phones to small Arduino edge devices, to large supercomputing systems, in every corner of the world we can see the figure of ARM. In order to promote SARS-Cov-2 vaccine research and development, they also formed a set of ARM64 general-purpose computing platform, the hardware used is Raspberry Pi 4, the system uses Ubuntu 20.04 aarch64, because the main focus of low power consumption, so the entire computing platform is running at home, 50 units of Raspberry Pi Power consumption is basically at 300-400 watts, at the same time, they are also setting up Kubernets under the machine learning platform, able to complete the training of models on ARM, of course, the performance and X86 + GPU can not be compared, overall they can learn to large distributed project training and cluster management experience on a large scale. ...

Books Introducing four great books written by Taleb: “Antifragile” Reading “The Black Swan” finished The Random Walk for Dummies not read “Asymmetric Risk” not read The Wisdom of Random Survival unread Knowledge Extension In looking at Taleb’s Black Swan, he has been emphasizing the properties of both Average Stan and Extreme Stan, while paying particular attention to the probabilistic understanding-fractal geometry, self-similarity theory in Extreme Stan. Here let me pay special attention to the conjecture that graph network is the cornerstone of the physical theory of the universe proposed by wolfram earlier this year, interested partners can go to wolframphysics to understand the specific content, simply speaking is to create complex universe by a simple rule, and then by these multiplying models of the universe to explain our existing edifice of physics theory. In fractal theory, a certain rule reproduces the wonderful geometry of nature by constantly iterating itself, which is the self-similar structure that Taleb has been describing in his books, so at present one focuses a lot of attention on the two areas of randomness and fractal geometry, and the use of fractal geometry may lead to a new breakthrough in machine learning. ...

I booked reMarkable2 ink screen handwritten electronic tablet book in March, due to the epidemic, I should have received it in July, but only yesterday I received the goods, the whole product packaging is very artistic part, the reason for buying this product is to facilitate their own travel when they can. The battery life is also particularly long, basically look at the book can be used for 3-5 days, compared to a tablet like the iPad the advantage of the product is probably that is ink screen, the resolution 1872 * 1404 (226 DPI) basically will not appear blurred fonts. Usually at home, you can look at paper books, go out to work or travel with reMarkable2 can easily and quickly complete the study, will focus on reading and taking notes. ...

icosavax-vaccine-pipeline doing…

References [Polkadot Lightpaper] () Polkadot architecture Polkadot is called a next-generation blockchain protocol, which is a multi-chain system that allows the exchange of data between any other blockchain, in contrast to the common [PoW](https://en.wikipedia.org/wiki/Proof_ of_work) mining than the common PoW mining, I prefer something like Polkadot to generate blocks through NPoS, where we can directly run nodes on thousands of edge devices, which makes the whole chain with stronger security and decentralization of the whole chain. ...

From Rosetta@home to Folding@home Let’s start with the main principle. Rosetta@home is only predicting the molecular structure of synthetic drugs capable of Binding Covid-19 outer spike-in protein, which can be imagined as similar to the photographic technique in photography. Rosetta can statically predict the characteristics of a particular protein, but it cannot predict how that protein molecule will function under the evolution of time. Because there will be potential differences between molecules that generate electromagnetic forces, and all the constituent elements within the molecule will interact with each other to create motion over time, when we design a synthetic drug in Rosetta that can bind the SARS-COV-2 virus, we need to enter the testing phase to see if the drug can bind to the viral protein stably, because the predicted structure is static, we cannot know whether the protein structure can bind well to the viral protein under the interaction motion, here Folding@home comes in handy, it is similar to shooting a motion picture in photography, we can get the static protein structure chain from Rosetta@home, and then simulate in Folding@home whether that protein binds well to the viral protein over time to produce resistance to the virus. ...